CIBN Essay Example | Topics and Well Written Essays - 250 words

CIBN - Essay Example Admitting the importance of negotiability, the convention has made a difference between the statuses of holder based on the limitation of his rights. Hence, the rights of a protected holder are freed from claims and defences to a greater extent. The article 45 of the convention gives warranty for an instrument in the case of transfer that it does not bear any unauthorized signature and it has not been materially altered. The convention introduces many beneficial provisions. It permits an instrument to bear an interest at a variable rate in accordance with the provisions mentioned in the instrument and in relation to reference rates published. However, Uniform Commercial Code does not insist payment of interest unless it is an interest-bearing instrument. It also allows reference to a foreign exchange rate such as a bank exchange rate at a certain date in a certain place. The convention also allows payment in installments at successive dates. The convention has a provision to make pay ments in unit of value other than the currency.

Research paper proposal Example | Topics and Well Written Essays - 750 words

Proposal - Research Paper Example (Hunt, 1) Therefore, this research paper is an endeavor to realize the various aspects of children's literature, including its history, characteristics, elements that make good children's literature, and how it formulates good readers etc. The annotated bibliography of this paper suggests the seminal elements in this research paper. The book Children's Literature: Developing Good Readers by Nuba, Sheiman, and Searson is a valuable resource in the study of children's literature as it deals with the history, the essential factors, etc of children's literature and introduces the area in great detail. This also helps in an analysis of the role of children's literature as the articles by eminent writers suggest how it creates good readers and includes a list of valuable resources of children's literature. The illustrated version of the text by Silvey is most valuable in a profound analysis of children's literature. The various entries in the text also help the researcher in dealing with the most essential and minute aspects of children's literature. ... Griswold, Jerry and Jerome Griswold. Feeling Like a Kid: Childhood and Children's Literature. JHU Press. 2006. P 1-148. The book by Jerry and Griswold has essential value in the research as develop on the five basic themes in classic and popular works of children's literature such as snugness, scariness, smallness, lightness, and aliveness. The discussions in the text also help one in determining the essential characteristics of children's literature and, therefore, it is a valuable resource for the research. Cecil, Nancy Lee and Patricia Roberts. Families in Children's Literature: A Resource Guide, Grades 4-8. Libraries Unlimited. 1998. This resource has a key role in the analysis of children's literature in relation to family and "teachers and librarians...find helpful activities for using children's literature as a resource to acquaint middle-school children with the myriad ways families of all races and cultures live." (Cecil and Roberts, xii) The book deals with diverse family groups, heritage and traditions, relationships and conflicts within families, etc in relation to children's literature. Hunt, Peter. Children's Literature. London: Blackwell Publishing. 2001. P 1. Hunt's book is most useful in understanding children's literature and its importance based on valuable theoretical perspectives. Along with a valuable account of the history of children's literature, the book also provides an essential guide to the writings by the most celebrated writers of children's literature. Therefore, this resource is an important contributor to the analysis of children's literature and its various essential elements. Works Cited Ballew, Vince and

Human Development Essay Example for Free

Human Development Essay Taking a look at the Human Development Index map of Africa, which can be seen on (http://en.wikipedia.org/wiki/Human_Development_Index) on the web; it shows that many of Africas countries are very underdeveloped.7 One of the obvious reasons for why countries is Africa are underachieving is because of how poor is the strength of their economy compared to others. As it is well known, Africa is very rich in mineral resources as many other states rely upon their, possessing most of the known minerals types of the world. Africas economy is more reliant on agriculture than that of any other continent, with around 60% of Africans working in the agricultural sector. Secondly, the economic development of virtually all African nations has been hindered by inadequate transportation systems. Most countries rely on road networks that are composed largely of dirt roads, which become impassable during the rainy seasons. Road networks tend to link the interior of a country to the coast; few road systems link adjacent countries.9 To show how poor and how bad economy crisis is in Africa, one ought to take a look at their food crisis and the growing volume of food imports. Whereas Africa imported an average volume of 1.96 million metric tons of agricultural products in the years 1961-63, by 1980-82 this figure had risen to 11.2 million metric tons at an annual value of over $6.8 billion (over one-seventh of the total value of Africas imports in 1982).Owing to foreign exchange constraints, most African countries have had to rely increasingly on food aid to meet their imported food requirements.10 The commercial sectors of most African states rely heavily on one or a few export commodities. The bulk of trade occurs with industrialized nations, which require raw materials and sell industrial and consumer goods. Trade between African states is limited by the competitive, rather than complementary, nature of their products and by trade barriers, such as tariffs, and the diversity of currencies. Looking at the economy of Europe, a sharp contrast in strength and influence can visibly be seen. Europe has long been a world leader in economic activities. As the birthplace of modern science and of the Industrial Revolution, Europe acquired technological superiority over the rest of the world, which gave it unquestioned dominance in the 19th Century. An important impetus for growth since the mid-20th Century has been the formation of supranational organisations such as the European Union, the European Free Trade Association, and the Organisation for Economic Cooperation and Development. Unlike Africa, Europe has highly developed transport systems, which are densest in the central part of the continent. Many countries in Europe use well maintained transportation systems to transport important goods such as water transport which plays a major role in the European economy. Almost all European countries maintain national airlines, and several, such as Air France, British Airways, Swissair, Germany, and Netherlands are major worldwide carriers.13 Looking at both economies and trade, it is unquestionably obvious that Europe conducts substantial international trade compared to Africa. For Europe, much of its trade is intra-continental, especially among members of the European Union, but also engages in large-scale trade with countries of other continents. Germany, France, Great Britain, Italy and the Netherlands are among the worlds greatest trading nations. A large portion of European inter-continental trade involves the exporting of manufactured goods and the importing o f raw materials. Europes agricultural sector is generally highly developed, especially in Western Europe. The agricultural sector in Europe is helped by the Common Agricultural Policy, which provides farmers with a minimal price for their products and subsidized their exports, which increases competitiveness for their products. This policy is highly controversial as it hampers free trade worldwide (protectionism sparks protectionism from other countries and trade blocs: the concept of trade wars) and is violating the concept of fair trade.15 Africas economy is more reliant on primary products (i.e, agricultural and mineral) than that of any other continent, with around 60% of Africans working in the agricultural sector. About three fifths of African farmers are subsistence farmers tilling small pots of land to feed their families, with only a minimal surplus that can be sold for other goods.16 However, there are significant number of large farms that grow cash crop such as coffee, cotton, cocoa, and rubber; these farms, normally operated by large corporations, cover tens of square kilometres and employ large number of labourers. Africas geography is unsuited to trade and thus hampers its economy. The centre of the continent, at least on the western side, is an almost impenetrable rainforest that greatly impedes the transit of people of goods. Some of the wealthiest parts of South Africa are blocked from the rest of Africa by the Kalahari Desert, while the Sahara creates an obvious barrier to trade. While Africa has a number of great river systems such as those of the Nile, Niger, Congo, and Zambezi, it is not nearly as well-linked rivers as are other areas such as Europe. Moreover, many of the rivers are blocked by rapids and cataracts that require vast development projects if they are to be bypassed. The wetness of the roads and tracks makes transport difficult and hazardous. In addition Africa is cut off from the sea to a greater extent than any other continent. To enforce even more problems to Africa; there is an increasing amount of desertification occurring in Africa where the deserts, especially the Sahara are becoming larger, enveloping area around them, leaving less space for land. This process is partly due to the deforestation of areas of forest; with no roots to hold soil in place, it blows away leaving an infertile desert. Europe has a well developed financial sector. Many European cities are financial centres with the City of London being the largest.19 The European financial sector is helped by the introduction of the euro as common currency. This has made it easier for European households and firms to invest in companies and deposit on banks in other European countries as exchange rate fluctuations are now non-existent in Europe. As mentioned above, Europes economy is superior to that of Africa, so what can Africa do to improve its economy or perhaps what can it take from the Europe economy as a model. Professor J A. van Ginkel held a conference on the Knowledge and Development in Africa; here he talked about ways to improve Africas economy however not only by getting the economic policies right.20 Prof van Ginkel mentions that there is now substantial evidence that institutional weakness in many African countries is a critical obstacle to economic performance.21 From the surveys he conducted on the obstacles to business in Africa it highlights the damage caused by: the unpredictability of changes in laws and policies, the unreliability of law enforcement, and the impact of corrupt bureaucracies.22 Unless governments eliminate these kinds of obstacles then it is unlikely that the economy whether it is just locally in certain parts of Africa or on a national front will flourish. An aspect of the Europe model that Africa can learn from is the aspect of knowledge. No commodity is more expensive than knowledge. An Africa without a sustainable, strong knowledge sector of its own will always remain in a dangerously dependent position. Research and training institutions on the continent can make a critical contribution in at least three ways: by making the most of existing indigenous knowledge; by accessing the vast reservoir of existing global knowledge, as well as the ongoing advances in understanding, and adapting them to suit specific local conditions; and by helping to find innovative solutions to seemingly intractable problems.23 In terms of human resources, it was highlighted in the Seminars of Anticipation that African developments suffers from a tragic paradox: on the one hand, elites trained in Western world are too many (and most of them stay in the US or in the EU because they cannot find well-paid qualified positions in Africa, or because their skills do not correspond to African needs); while on the other hand the well-trained intermediate executives required to manage a modern economy are cruelly missing in Africa (higher technical experts, management executives, civil administrators). To conclude, this essay has looked the economies of both Europe and Africa and compared and contrast both of them. It has also provided information about both economies in terms of trade and finance. A brief history was provided which looked at the relationship between Europe and Africa and to the days of colonisation. Reasons as to why both regions are on different levels economically were provided to show how dominant and rich Europe was and how poor and underdeveloped Africa was. The Africa food crisis was mentioned to give an account of how poor Africa was against other regions. In addition ways that Africa can improve their economy thus bringing it more power and strength so that it can compete with other regions was provided, for example making sure Africa had the aqeduate education so that it learn. Many Africans move to the west so that they can have higher education which is not available in Africa and tend to stay there once they have completed their studies. This is detrimental to Africas development and thus a solution to the problem would be to support the creation of a complete curriculum. This would lead to a massive contribution to the development of vocational and technical education in Africa thus improving Africas economy. So as it can seen, the economies for both Europe and Africa are at this present time in contrast to each other but there is hope for Africa to become more dominant and influential in world affairs if the correct adjustments and policies are introduced to improve them. References Fawcett, L., Hurrell, A., Regionalism in World Politics, Oxford, Oxford University Press, 1995, pg 43Â  Ravenhill. J, Africa in economic crisis, Basingstoke, Macmillan, 1986, pg 9Â  www.ciaonet.org/isa/rajo

Low-grade Rhabdoid Meningioma: Morphological Characteristics

Low-grade Rhabdoid Meningioma: Morphological Characteristics Arvids Jakovlevs, Andrejs Vanags, Janis Gardovskis, Ilze Strumfa SUMMARY Rhabdoid meningioma (RM) is a rare type of meningioma. It is classified as a grade III tumour (anaplastic meningioma) in the recent World Health Organization (WHO) classification of the tumours of the central nervous system (CNS). Here we describe a unique case of RM lacking any features of malignancy. Few cases of low-grade RMs are described in the literature in contrast with the grading of this entity in WHO classification. Key words: meningioma, rhabdoid, low-grade AIM OF THE DEMONSTRATION The aim of our article is to report a case of unusual RM lacking malignant features in regard to the issue about the prognostic significance of rhabdoid morphology in meningiomas. CASE REPORT A 37-year-old woman was admitted to the hospital due to progressive headaches over previous 1.5 years. The magnetic resonance imaging of head and brain revealed a well-demarcated intracranial lesion measuring 3.53.63.6 cm (Figure 1A). The mass was located adjacent to the frontal bone and was attached to the dura mater. The patient underwent a craniotomy and total tumour resection. Histological examination of the neoplasm revealed cells consistent with rhabdoid morphology. The tumour was almost entirely composed of polygonal, rather large cells that possessed eccentric nuclei, strongly eosinophilic cytoplasm with abundant pale globular inclusions and prominent cytoplasmic granularity (Figure 1B). The nuclei of neoplastic cells were slightly pleomorphic. Mitoses were absent in the whole specimen. In addition, the tumour had well-developed fibrous capsule that demarcated it from normal brain tissues. Psammoma bodies were found in some areas of the tumour. Immunohistochemical visualizati on (IHC) showed intense cytoplasmic expression of vimentin and epithelial membrane antigen (Figure 1C-D) as well as strong nuclear expression of progesterone receptors in the tumour cells. The neoplastic cells did not express smooth muscle actin, desmin, HMB-45, S-100 protein, kappa and lambda light chains. Ki-67 proliferation index was as low as 1.5 %. Thus, the morphological appearance and immunohistochemical features were consistent with RM and low-grade cellular characteristics. DISCUSSION Tumours with rhabdoid morphology were first described in 1978 in relation to malignant renal tumours of children (1). Nowadays, many tumours with rhabdoid morphology are known in different localizations including CNS and meninges. Rhabdoid cells have no evidence of myogenic origin. The term „rhabdoid† is used to denote close histological resemblance of tumour cells to rhabdomyoblasts. Rhabdoid cells are characterized by typical light microscopic morphology: round cells with eccentric, vesicular nuclei, prominent nucleoli and eosinophilic cytoplasm with paranuclear globular inclusions (3). Meningiomas developing from the meninges are among the most common intracranial tumours. Regarding these tumours, surgery is the mainstay of treatment, and neurosurgeon also is involved in the planning of further observation and treatment in accordance to the tumour grade (5). Meningiomas show wide range of histopathological appearances. While the majority of meningiomas are benign tumours (WHO grade I meningiomas), some meningiomas have increased risk of local recurrences (WHO grade II meningiomas) and the minority are truly malignant and have a risk of metastatic dissemination; these are classified as WHO grade III meningiomas (2). RM is an uncommon type of meningioma which was described for the first time in 1998 (3). It was found that rhabdoid morphology in meningiomas was associated with a worse prognosis (3). Soon after this finding RM was separated as a distinct entity in WHO classification of CNS tumours published in 2000. RM has been classified as a grade III neoplasm by WHO (2). Consistent with the malignant behaviour, significant mitotic activity, anaplasia and other atypical features are usually found in RMs (2, 4). However, there are some isolated reports of RMs with no evidence of cellular atypia (6). In our case diagnosis of RM was established due to pure rhabdoid morphology along with meningothelial origin that was clearly demonstrated by IHC. Absence of atypia in the tumour cells and low Ki-67 proliferation index was consistent with low-grade meningioma in the present case. In conclusion, rhabdoid meningioma occasionally lacks histological features of malignancy that can lead to confusion if the rhabdoid morphology is always associated with malignant behaviour. Increased awareness of low-grade rhabdoid meningiomas is necessary to estimate the prognosis and to plan the treatment appropriately. REFERENCES Beckwith JB, Palmer NF. Histopathology and prognosis of Wilms tumors: results from the First National Wilms’ Tumor Study // Cancer, 1978; 41:1937 – 1948 Cooper WA, Shingde M, Lee VK, Allan RS, Wills EJ, Harper C. â€Å"Rhabdoid meningioma† lacking malignant features. Report of two cases // Clin Neuropathol, 2004; 23(1):16 – 20 Louis DN, Ohgaki H, Wiestler OD, Cavenee WK. Meningeal tumors // In: Bosman FT, Jaffe ES, Lakhani RS, Ohgaki H. WHO Classification of tumours of the central nervous system. 4th edition. Lyon: IARC; 2007; 164-180 Perry A, Scheithauer BW, Stafford SL, Abell-Aleff PC, Meyer FB. Rhabdoid meningioma: an aggressive variant // Am J Surg Pathol, 1998; 22:1482 – 1490 Walcott BP, Nahed BV, Brastianos PK, Loeffler JS. Radiation treatment for WHO grade II and III meningiomas // Front Oncol, 2013; 3:227, doi:10.3389/fonc.2013.00227 Zhou Y, Xie Q, Gong Y, Mao Y, Zhong P, Che X, Jiang C, Huang F, Zheng K, Li S, Gu Y, Bao W, Yang B, Wu J, Wang Y, Chen H, Xie L, Zheng M, Tang H. Clinicopathological analysis of rhabdoid meningiomas: Report of 12 cases and a systematic review of the literature // World Neurosurg, 2013; 79(5-6):724 – 732 3t-Alkyl-2r,6c-diarylpiperidin-4-ones: Synthesis 3t-Alkyl-2r,6c-diarylpiperidin-4-ones: Synthesis 3t-Alkyl-2r,6c-diarylpiperidin-4-ones Synthesis A very convenient and non-laborious one-pot synthesis method developed by Noller and Baliah [50] has been used successfully for the synthesis of 3t-alkyl-2r, 6c-diarylpiperidin-4-ones 32 by the condensation of methyl ketones, aromatic aldehydes and ammonium acetate in 1:2:1 molar ratio (Scheme 13). It’s a non-laborious one-pot synthesis of 3t-alkyl-2r, 6c-diarylpiperidin-4-ones 32. Various substituted piperidin-4-ones were also synthesized by adapting the above method [53-,57]. Often used typical procedure reported by Baliah and Jeyaraman was adapted to synthesis several substituted 3t-alkyl-2r,6c-difuranylpiperidin-4-ones 33 and 3t-benzyl-2r,6c-diarylpiperidin-4-ones 34 with convenient modification [58,59]. Seven r(2),c(4)-bis(isopropoxycarbonyl)-t(3)-aryl-c(5)-hydroxy-t(5)-methylcyclohexano-nes (aryl = C6H5, p-ClC6H4, p-FC6H4, p-OMeC6H4, p-Me2NC6H4, m-O2NC6H4 and m-C6H5OC6H4) have been synthesized by condensing isopropyl acetoacetate with aromatic aldehydes in the presence of methylamine [53]. Aridoss et al have synthesized an array of novel N-morpholinoacetyl-2,6-diarylpiperidin-4-ones as well as imidazo(4,5-b) pyridinylethoxypiperidones and Structure and stereochemistry of all the N-morpholinoacetyl-2,6-diarylpiperidin-4-ones have been analyzed using 1H and 13C NMR spectroscopic techniques [54,55]. 1H and 13C NMR spectra have been recorded for 2r,6c-diarylpiperidin-4-one (3_-hydroxy-2_naphthoyl)hydrazones and 3,3-dimethyl-2r,6c-bis(p-methoxyphenyl)piperidin-4-one [56-57]. Conversion to other derivatives Other derivatives from piperidin-4-ones have been obtained which includes oximes 35 [60-73], hydrazones 36 [57,74], semicarbazones 37 [75], thiosemicarbazones 38 [69], and phenylhydrazones 39 [76] by the reaction of the carbonyl group with suitable reagents. 2r,6c-diarylpiperidin-4-ones have been reduced to obtain 4t-Hydroxy-2r, 6c-diphenylpiperidines 40a and 4c-hydroxy-2r,6c-diphenylpiperidines 40b. N-substituted 2r,6c-diarylpiperidin-4-ones 41-51 was obtained by the reaction of the NH function with suitable reagents have been reported (Scheme 13) [77-84]. Physico-chemical studies Several physico-chemical studies have been performed for 3t-Alkyl-2r,6c-diarylpiperidin-4-ones and their derivatives [64-91]. Several studies have documented the conformations of various substituted 2,6-diarylpiperidin-4-ones [78,86]. Pandiarajan et al. [88] have elaborately discussed the conformations of 32 and suggested chair conformation to these compounds with equatorial disposition of the aryl and alkyl substituents based on their NMR spectral data. Substitution of alkyl group at C-3 position of the piperidine ring causes the ring to flatten slightly about C(2)-C(3) bond probably to decrease gauche interaction between aryl and alkyl groups at C(2) and C(3). Stereochemistry of N-acetyl and N-benzoyl-2r,6c-diphenylpiperidin-4-one oximes 5256 has been already reported [89]. Synthesis and conformation of 3t-chloro-2r,6c-diarylpiperidin-4-ones 57 also been reported [90,91]. Manimekalai et al. [92] demonstrated the conformation of benzyl group in 4-benzyl-4-hydroxypiperidines 58. Pharmacological studies Many piperidine derivatives possess pharmacological activities including antimicrobial, antioxidant and anticancer activities and to form an essential part of the molecular structure of important drugs [9, 93-97]. Piperidin-4-ones have been used for development of compounds with selective biological activities include antiviral [98], antitumor [99], analgesic [100], local anesthetic [101,102], bactericidal [103], fungicidal [103], herbicidal [103], insecticidal [104], antihistaminic [104], anti-inflammatory [104], anticancer [105], CNS stimulant [105], antitubercular and depressant [106] activities. Earlier reports have clearly established that the biological activities[R1] of piperidin-4-ones were improved by incorporation of the substituents at C-2, C-3 and C-6 [106,107]. Ferguson documented that N-nitrosopiperidines are carcinogenic in nature and blocking of one of the à ¯Ã‚ Ã‚ ¡ position by an alkyl group significantly reduces the carcinogenic activity [108]. Lijinsky and Taylo r have also supports that blocking of à ¯Ã‚ Ã‚ ¡ positions to the N-nitroso group by methyl groups reduces the carcinogenic activity [109]. 3t,5t-Dimethyl-2r,6c-diarylpiperidin-4-one hydrochlorides 59-61 have shown anti-histaminic activity [110]. Furthermore, 3t,5t-dimethyl-2r,6c-bis(4-hydroxyphenyl)piperidin-4-one 62 and 3t-methyl-5-substitutedphenyl-2r,6c-diarylpiperidin-4-ones 63 showed antimicrobial, insecticidal and antihistaminic activities [111]. 2,3,6-Triarylpiperidin-4-ones 64 and their oximes exhibits marked bactericidal, fungicidal and herbicidal activities [104]. N-Substituted piperidin-4-one 65 and its derivatives 66 and 67 exhibited potential Juvenile hormone activity on Bombyx mori [112]. N-methyl-3E,5E-bis(arylidine)piperidin- 4-ones 68, possessing a variety of aryl and heteroaryl groups, showed antiviral and antitumor activities [98]. 3E,5E-Bis(benzylidene)piperidin-4-one 69, 1-acryloyl derivatives of 69, and 70 the adduct of 2-mercaptoethanesulfonic acid 71 as well as 3E,5E-Bis(thienylidene)-piperidin-4-ones 72 have shown antitumor activity towards human carcinoma cell lines Caov3, Scov3 and A549 [113]. Furthermore, modification of position 3 of the piperidin-4-one nucleus as well as a substitution of certain functional groups in the para position of phenyl ring attached to C-2 and C-6 carbons of the piperidine moiety would result in compounds of potent biological activities. Hydrazones Hydrazones are a class of organic compounds with azomethine -NHN=CH- proton that constitutes an important class of compounds for new drug development [10,97,98]. Hydrazone are formed usually by the action of hydrazine on ketones or aldehydes. Hydrazide-hydrazone derivatives receive the attention of various medicinal chemists as a result of their effectual biological potencies viz., antimicrobial, anti-tubercular, and also anticonvulsant actions [10,114-116]. Some hydrazones is known to act as herbicides, insecticides, nematocides, rodenticides and plant growth regulators. Several studies have documented the spasmolytic activity, hypotensive action and activity against leukaemia, sarcomas and other malignant neoplasms [114-116]. Many of the physiologically active hydrazones have applications in diseases like tuberculosis, leprosy and mental disorder are characterized by the presence of the triatomic group (>C=N–N73 [117]. Hydrazones are also useful in detection, determination and isolation of compounds containing the carbonyl group and many other metals [10]. Syringaldehyde hydrazones 74 and 6-nitro-3,4-methylene-dioxophenyl-N-acylhydrazone 75 exhibits antioxidant properties [118,119]. Hydrazone and its substituted derivatives showed good antibacterial, antifungal, anticonvulsant, antitubercular, anticancer and antitumor activities. 1-[4=[(2-[(4-Substitutedphenyl)methylene]hydrazine] carbonyl)phenyl]-3-substituted thioureas 76 exhibited good clinically active tuberculostat [120]. Some coupling products from 4-aminobenzoic acid hydrazones 77 and (7-Hydroxy-2-oxo-2H-chromen-4-yl)acetic hydrazide 78 showed antimicrobial activity [121,122]. A series of 4-fluorobenzoic acid (substituted methylene/ ethylidine) hydrazide derivatives 79 showed the chemotherapeutic antituberculosis activities [123]. Hemalatha et al have documented the antibacterial and antifungal activities of N-nitroso-2,6-diarylpiperidin-4-one semicarbazones [124]. Some bicyclic semicarbazones and thiosemicarbazones 81 showed a wide variety of biological activities [124]. The significance of fusing heterocycles Heterocycles possess an enormously diverse group of compounds, are widely distributed in nature. Heterocycles can be easily manipulated and modified by organic synthetic methods to increase or decrease reactivity. They are used extensively as intermediates in various reactions as well as building blocks in organic synthesis. Novel libraries of biologically diverse heterocyclic compounds have been synthesized by incorporation and substitution of a wide range of functional groups (ring activators or deactivators) and their positions around the ring of heterocycles. Several studies provide evidence that combination of two bio-active heterocyclic moieties together leads to the production of novel and biologically important compounds with the anticipation of several promising pharmacological agents [4,125]. Based on the above features discussed under 3t-Alkyl-2r,6c-diarylpiperidin-4-ones, 2r,4c-Diaryl-3-azabicyclo[3.3.1]nonan-9-ones and hydrazones, we have developed the system that fuse 3 -azabicyclonones/piperidin-4-one pharmacophore and hydrazide moieties together to produce the corresponding hydrazones with the anticipation of several promising antioxidant, anticancer and antimicrobial agents arising. The relevant technique used to elucidate the structure of the newly synthesized compounds Specialized spectroscopic instruments can be used to generate information that enables the determination of the structure of an unknown organic compound. This includes Infrared spectrometry (IR), nuclear magnetic spectrometry (NMR) and elemental analysis. Among all available spectrometric methods, NMR is the only technique which offers a complete analysis and interpretation of the entire spectrum [126,127]. A few of the strategies of NMR experiments that are used in determination of different compounds are described as follows. NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY Nuclear magnetic resonance spectroscopy, one of the most versatile techniques for elucidation of structure of organic compounds, has shown a tremendous progress due to improved experimental technology and novel approaches. In NMR, the most useful information comes from the interactions between two nuclei, either through the bonds which connect them (J-coupling interaction) or directly through space (NOE interaction) [126-128]. Interpretation of NMR spectra is well understood from the following basic information gathered from NMR spectra. 1) Chemical shift, which identifies the type of proton based on their electronic environment, 2) Spin-Spin splitting patterns, which identifies neighbouring protons, 3) Peak Area, which is proportional to the number of protons giving a particular resonance line, 4) The observation of a triplet and a quartet spin state confirming usually the presence of an ethyl group (CH3CH2) and 5) The observation of ÃŽ ´ values between 7.2-8.0 indicates that the structure contains a benzene ring (benzyl proton) [126-130]. Generally, three approaches are used in NMR spectroscopy methods. These include one dimension (1D), two dimensions (2D) and three dimensions (3D). The first approach of 1D-NMR (1H DEPT, 13C, 15N, 19F, 31P, etc.) generates good information about the structure of simple organic compounds. However, it is overcrowded in case e of larger molecules. The second approach of 2D-NMR (COSY, DQFCOSY, MQFCOSY, HETCOR, HSQC, HMQC, HMBC, TOCSY, NOESY, EXSY, etc.) is used for the further larger molecules. A 2D-NMR spectrum also becomes complex and overlapping in case of further very large molecules like proteins. Therefore, multi-Dimensional-NMR (Homonuclear and Heteronuclear) are generally used to achieve high resolution and reduced overlapping in spectra of very large molecules [126,128,129]. This section further describes the general interpretation of structure of different organic compounds by different NMR techniques. 1D NMR SPECTROSCOPY 1H-NMR: Spin transitions of only hydrogen nuclei are observed in in 1H-NMR spectroscopy. Table 1 represents different ÃŽ ´ values, couplings, coupling constants and chemical shifts of 1H nuclei processing in different chemical environments. Commonly, ÃŽ ´ value scale of 1H-NMR ranges from 0-10 ppm with respect to Tetra methyl Silane (TMS) as internal standard. 1H-NMR spectral interpretation can be best understood from table 4 [126,131]. 1H Chemical shifts Because of variations in the electron distribution, the variation of nuclear magnetic resonance frequencies of the same kind of nucleus is referred to as chemical shift (symbolized by ÃŽ ´). Quantitative chemical shift are measured in frequency (Hertz) relative to a standard, Tetra methyl silane (TMS). Characterization of the structure of a molecule is depending upon the position and number of chemical shifts [111,112,115]. The chemical shift range of 1H nuclei can also be understood from a chart given in figure 1 [126].The chemical shift values for methyl protons attached to groups of varied electronegativity are given below [127]: CH3I-2.16 CH3Br-2.18 CH3Cl-3.05 and CH3F-4.26 ppm, The electron density around the proton affects its chemical shift. Because of the e- density around the H nuclei, the CH3 protons come to resonance at higher ÏÆ' values as the electronegativity of a functional group is increased. Electronic charge surrounded to H nuclei shields the nucleus to some extent from the influence of the applied field. The magnetic flux overcomes this shielding effect in order to bring a proton to resonance. Thus, the higher the electron density around the proton, the greater the induced diamagnetic effect and the greater the external field required to overcome the shielding effect. Electro-ve groups like fluorine in CH3F withdraws e- density from the CH3 group (-inductive effect). This leads to de-shielding by lower value of an applied magnetic field in order bring the methyl proton to resonance. Fluorine is more electro-ve than Cl, thus the proton in CH3F appears at a higher ÃŽ ´ values than those in CH3Cl. The chemical shift positions for protons attache d to C=C in alkenes is higher compared to that of accounted by electronegative effect alone. Alkene and aromatic protons appear at high ÏÆ' values while alkyne C≠¡C protons appear at a relatively low ÃŽ ´ value [126,127,132]. The magnetic field created by pi electrons or rings is referred to as Magnetic anisotropy, which describes an environment where different magnetic fields are found at different points in space. Since Pi electrons are held less strongly than sigma electrons, pi electrons are more able to move in response to the magnetic field. The anisotropic effects of the à ¯Ã‚ Ã‚ ³ electrons of C-C bond is low compared to those of the circulating à ¯Ã‚ Ã‚ °-electrons. The equatorial protons in cyclohexane resonate at 0.5 ppm higher than the axial protons. This is due to the anisotropic effect of the à ¯Ã‚ Ã‚ ³-electron in the CÃŽ ²-Cà ¯Ã‚ Ã‚ § bonds [127,133] (Figure. 2). [R1]Specify which biological activity

Changes In The NHL :: essays research papers

Changes In The NHL   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚     Ã‚  Ã‚  Ã‚  Ã‚  In the past there were more goals, less penalties, and never any talk about an Olympic size rink, all that has changed in the last few years. The NHL has changed since the introduction of, the new crease rule, the enforcement of obstruction, and the request for an Olympic size rink.   Ã‚  Ã‚  Ã‚  Ã‚  The new crease rule is the most controversial rule change that the NHL has ever introduced. There has been less goals since the players have not been allowed to have even a toe in the goal crease when a player scores a goal. The old rule was that players were allowed to be in the crease as long as they don’t interfere with the goalie. The NHL has since made the crease smaller so that there is less chance of a player being in the crease, but that hasn’t changed the fact that players are still in the crease when a player scores a goal. On average there has been at least two goals a night called back since the new crease rule.   Ã‚  Ã‚  Ã‚  Ã‚  The obstruction rule has been one of the best rule changes ever in the NHL. Players are not allowed to interfere with other players if they are going into the play were the puck is. This new rule has cleaned up the game of hockey tremendously. Some of the obstruction calls are, obstruction hooking, obstruction holding, obstruction tripping, so on, and so forth. When the obstruction rule first came into effect there was way more penalties, now the penalties are becoming less.   Ã‚  Ã‚  Ã‚  Ã‚  The request for an Olympic size rink still has not been approved by the NHL. The NHL has talked about upgrading their regular size rink to an Olympic size one. If the NHL comes to an agreement to go to the Olympic size rink, the game would be a lot faster, a lot more open, and there would be many more great set up plays.

Heart Of Darkness :: essays research papers fc

The Horror Heart of Darkness by Joseph Conrad is a novel where the main character Marlow is telling a story of a trip to the Congo. This novel is said to possibly be an autobiography of Conrad’s life at sea. This is said because Conrad was a seaman for a many years and went into Africa many times. The story is so powerful that even after 100 years, we still struggle with its meaning. This story has been retold by Francis Ford Coppola in the film Apocalypse Now. Chinua Achebe has recently explored Conrad’s ideas on imperialism. Achebe believed Conrad’s book presented a racist view of the people of Africa and Achebe in his own book, Things Fall Apart, presented imperialism through the eyes of the Africans. The story of Heart of Darkness is being told to four men on the deck of the Nellie. The story being told is about one of Marlow’s expeditions to the Congo in search of an Ivory hunter named Kurtz. When Marlow found Kurtz in the Congo, Kurtz had "gone native" Marlow found, "a head that seemed to sleep at the top of that pole," outside of Kurtz’s house and Kurtz had been hunting with tribes in the area (Conrad, 73). When Marlow arrived Kurtz, was ill and dying. Kurtz cried out the words "The horror! The horror!" right before he died (Conrad, 85). These words cried out by Kurtz as he died created the most important passages in Heart of Darkness. The way this one passage is interpreted determines how the book is interpreted. One interpretation is that the "horror" is death and Kurtz is realizing he is dying. Kurtz is horrified at the thought of dying and is crying out in pain of the realization. Kurtz may be afraid to die in the heart of darkness. Kurtz may be afraid to die knowing that he will never see his intended again and he may feel guilty for leaving his intended for his savage life. This interpretation shows a book about lost love and guilt for finding a new life. This interpretation is one of the less complex and uninteresting interpretations. Now here is a more interesting and complex interpretation. Some view Heart of Darkness as a racist book. This interpretation comes from the view that the "horror" Kurtz is identifying is his being brought "down" to the African ways. This interpretation sees the African ways as uncivilized and horrid to Kurtz when he realizes he was at their level.

The Unique Corporate Culture in Google

The Unique Corporate Culture in Google Executive Summary The internet giant of search engine â€Å"Google†, always rated for the â€Å"Best Workplace†, â€Å"Best Employer† in the recent ten years. Why? Except the professional technology, Google’s great and unique corporate culture made so. The feature of Google’s corporate culture is equality, free and human oriented.The company provide the most luxury and comfortable work environment to its employee, encourage them relax more, play hard and work hard. From Google’s case, more and more companies realized the perks and benefits for the employee are no longer only medical, insurance, overtime pay, free coffee and two weeks holidays. In Google, nobody need to punch the clock, you can work in your own â€Å"time zone†.If you don’t want to leave your pet in the working time, bring it in your office, you can stay with it in every minute. You don’t need bring the lunch box to t he company, because it has free breakfast, lunch and dinner every day. Vast kinds of facilities are well-established. Like the professional massagist, the gym, the massage chair, the bicycle, the dry clean laundry, the slides, the electronic scooter, the oil change, and so on.Everything seems great, but if the employee has other demand, they can speak to the founder or CEO directly, maybe the request would be excessive or crazy, but if it is feasible, Google will satisfy employee in every possible way. The open policy reflects the equality in Google. Every employee can see the boss and co-workers work plan and schedule. Google think this way can let all employees get the information about company’s program progress and developing direction, make them feel they are trusted and will be one of the groups always.