Low-grade Rhabdoid Meningioma: Morphological Characteristics

Low-grade Rhabdoid Meningioma: Morphological Characteristics Arvids Jakovlevs, Andrejs Vanags, Janis Gardovskis, Ilze Strumfa SUMMARY Rhabdoid meningioma (RM) is a rare type of meningioma. It is classified as a grade III tumour (anaplastic meningioma) in the recent World Health Organization (WHO) classification of the tumours of the central nervous system (CNS). Here we describe a unique case of RM lacking any features of malignancy. Few cases of low-grade RMs are described in the literature in contrast with the grading of this entity in WHO classification. Key words: meningioma, rhabdoid, low-grade AIM OF THE DEMONSTRATION The aim of our article is to report a case of unusual RM lacking malignant features in regard to the issue about the prognostic significance of rhabdoid morphology in meningiomas. CASE REPORT A 37-year-old woman was admitted to the hospital due to progressive headaches over previous 1.5 years. The magnetic resonance imaging of head and brain revealed a well-demarcated intracranial lesion measuring 3.53.63.6 cm (Figure 1A). The mass was located adjacent to the frontal bone and was attached to the dura mater. The patient underwent a craniotomy and total tumour resection. Histological examination of the neoplasm revealed cells consistent with rhabdoid morphology. The tumour was almost entirely composed of polygonal, rather large cells that possessed eccentric nuclei, strongly eosinophilic cytoplasm with abundant pale globular inclusions and prominent cytoplasmic granularity (Figure 1B). The nuclei of neoplastic cells were slightly pleomorphic. Mitoses were absent in the whole specimen. In addition, the tumour had well-developed fibrous capsule that demarcated it from normal brain tissues. Psammoma bodies were found in some areas of the tumour. Immunohistochemical visualizati on (IHC) showed intense cytoplasmic expression of vimentin and epithelial membrane antigen (Figure 1C-D) as well as strong nuclear expression of progesterone receptors in the tumour cells. The neoplastic cells did not express smooth muscle actin, desmin, HMB-45, S-100 protein, kappa and lambda light chains. Ki-67 proliferation index was as low as 1.5 %. Thus, the morphological appearance and immunohistochemical features were consistent with RM and low-grade cellular characteristics. DISCUSSION Tumours with rhabdoid morphology were first described in 1978 in relation to malignant renal tumours of children (1). Nowadays, many tumours with rhabdoid morphology are known in different localizations including CNS and meninges. Rhabdoid cells have no evidence of myogenic origin. The term „rhabdoid† is used to denote close histological resemblance of tumour cells to rhabdomyoblasts. Rhabdoid cells are characterized by typical light microscopic morphology: round cells with eccentric, vesicular nuclei, prominent nucleoli and eosinophilic cytoplasm with paranuclear globular inclusions (3). Meningiomas developing from the meninges are among the most common intracranial tumours. Regarding these tumours, surgery is the mainstay of treatment, and neurosurgeon also is involved in the planning of further observation and treatment in accordance to the tumour grade (5). Meningiomas show wide range of histopathological appearances. While the majority of meningiomas are benign tumours (WHO grade I meningiomas), some meningiomas have increased risk of local recurrences (WHO grade II meningiomas) and the minority are truly malignant and have a risk of metastatic dissemination; these are classified as WHO grade III meningiomas (2). RM is an uncommon type of meningioma which was described for the first time in 1998 (3). It was found that rhabdoid morphology in meningiomas was associated with a worse prognosis (3). Soon after this finding RM was separated as a distinct entity in WHO classification of CNS tumours published in 2000. RM has been classified as a grade III neoplasm by WHO (2). Consistent with the malignant behaviour, significant mitotic activity, anaplasia and other atypical features are usually found in RMs (2, 4). However, there are some isolated reports of RMs with no evidence of cellular atypia (6). In our case diagnosis of RM was established due to pure rhabdoid morphology along with meningothelial origin that was clearly demonstrated by IHC. Absence of atypia in the tumour cells and low Ki-67 proliferation index was consistent with low-grade meningioma in the present case. In conclusion, rhabdoid meningioma occasionally lacks histological features of malignancy that can lead to confusion if the rhabdoid morphology is always associated with malignant behaviour. Increased awareness of low-grade rhabdoid meningiomas is necessary to estimate the prognosis and to plan the treatment appropriately. REFERENCES Beckwith JB, Palmer NF. Histopathology and prognosis of Wilms tumors: results from the First National Wilms’ Tumor Study // Cancer, 1978; 41:1937 – 1948 Cooper WA, Shingde M, Lee VK, Allan RS, Wills EJ, Harper C. â€Å"Rhabdoid meningioma† lacking malignant features. Report of two cases // Clin Neuropathol, 2004; 23(1):16 – 20 Louis DN, Ohgaki H, Wiestler OD, Cavenee WK. Meningeal tumors // In: Bosman FT, Jaffe ES, Lakhani RS, Ohgaki H. WHO Classification of tumours of the central nervous system. 4th edition. Lyon: IARC; 2007; 164-180 Perry A, Scheithauer BW, Stafford SL, Abell-Aleff PC, Meyer FB. Rhabdoid meningioma: an aggressive variant // Am J Surg Pathol, 1998; 22:1482 – 1490 Walcott BP, Nahed BV, Brastianos PK, Loeffler JS. Radiation treatment for WHO grade II and III meningiomas // Front Oncol, 2013; 3:227, doi:10.3389/fonc.2013.00227 Zhou Y, Xie Q, Gong Y, Mao Y, Zhong P, Che X, Jiang C, Huang F, Zheng K, Li S, Gu Y, Bao W, Yang B, Wu J, Wang Y, Chen H, Xie L, Zheng M, Tang H. Clinicopathological analysis of rhabdoid meningiomas: Report of 12 cases and a systematic review of the literature // World Neurosurg, 2013; 79(5-6):724 – 732 3t-Alkyl-2r,6c-diarylpiperidin-4-ones: Synthesis 3t-Alkyl-2r,6c-diarylpiperidin-4-ones: Synthesis 3t-Alkyl-2r,6c-diarylpiperidin-4-ones Synthesis A very convenient and non-laborious one-pot synthesis method developed by Noller and Baliah [50] has been used successfully for the synthesis of 3t-alkyl-2r, 6c-diarylpiperidin-4-ones 32 by the condensation of methyl ketones, aromatic aldehydes and ammonium acetate in 1:2:1 molar ratio (Scheme 13). It’s a non-laborious one-pot synthesis of 3t-alkyl-2r, 6c-diarylpiperidin-4-ones 32. Various substituted piperidin-4-ones were also synthesized by adapting the above method [53-,57]. Often used typical procedure reported by Baliah and Jeyaraman was adapted to synthesis several substituted 3t-alkyl-2r,6c-difuranylpiperidin-4-ones 33 and 3t-benzyl-2r,6c-diarylpiperidin-4-ones 34 with convenient modification [58,59]. Seven r(2),c(4)-bis(isopropoxycarbonyl)-t(3)-aryl-c(5)-hydroxy-t(5)-methylcyclohexano-nes (aryl = C6H5, p-ClC6H4, p-FC6H4, p-OMeC6H4, p-Me2NC6H4, m-O2NC6H4 and m-C6H5OC6H4) have been synthesized by condensing isopropyl acetoacetate with aromatic aldehydes in the presence of methylamine [53]. Aridoss et al have synthesized an array of novel N-morpholinoacetyl-2,6-diarylpiperidin-4-ones as well as imidazo(4,5-b) pyridinylethoxypiperidones and Structure and stereochemistry of all the N-morpholinoacetyl-2,6-diarylpiperidin-4-ones have been analyzed using 1H and 13C NMR spectroscopic techniques [54,55]. 1H and 13C NMR spectra have been recorded for 2r,6c-diarylpiperidin-4-one (3_-hydroxy-2_naphthoyl)hydrazones and 3,3-dimethyl-2r,6c-bis(p-methoxyphenyl)piperidin-4-one [56-57]. Conversion to other derivatives Other derivatives from piperidin-4-ones have been obtained which includes oximes 35 [60-73], hydrazones 36 [57,74], semicarbazones 37 [75], thiosemicarbazones 38 [69], and phenylhydrazones 39 [76] by the reaction of the carbonyl group with suitable reagents. 2r,6c-diarylpiperidin-4-ones have been reduced to obtain 4t-Hydroxy-2r, 6c-diphenylpiperidines 40a and 4c-hydroxy-2r,6c-diphenylpiperidines 40b. N-substituted 2r,6c-diarylpiperidin-4-ones 41-51 was obtained by the reaction of the NH function with suitable reagents have been reported (Scheme 13) [77-84]. Physico-chemical studies Several physico-chemical studies have been performed for 3t-Alkyl-2r,6c-diarylpiperidin-4-ones and their derivatives [64-91]. Several studies have documented the conformations of various substituted 2,6-diarylpiperidin-4-ones [78,86]. Pandiarajan et al. [88] have elaborately discussed the conformations of 32 and suggested chair conformation to these compounds with equatorial disposition of the aryl and alkyl substituents based on their NMR spectral data. Substitution of alkyl group at C-3 position of the piperidine ring causes the ring to flatten slightly about C(2)-C(3) bond probably to decrease gauche interaction between aryl and alkyl groups at C(2) and C(3). Stereochemistry of N-acetyl and N-benzoyl-2r,6c-diphenylpiperidin-4-one oximes 5256 has been already reported [89]. Synthesis and conformation of 3t-chloro-2r,6c-diarylpiperidin-4-ones 57 also been reported [90,91]. Manimekalai et al. [92] demonstrated the conformation of benzyl group in 4-benzyl-4-hydroxypiperidines 58. Pharmacological studies Many piperidine derivatives possess pharmacological activities including antimicrobial, antioxidant and anticancer activities and to form an essential part of the molecular structure of important drugs [9, 93-97]. Piperidin-4-ones have been used for development of compounds with selective biological activities include antiviral [98], antitumor [99], analgesic [100], local anesthetic [101,102], bactericidal [103], fungicidal [103], herbicidal [103], insecticidal [104], antihistaminic [104], anti-inflammatory [104], anticancer [105], CNS stimulant [105], antitubercular and depressant [106] activities. Earlier reports have clearly established that the biological activities[R1] of piperidin-4-ones were improved by incorporation of the substituents at C-2, C-3 and C-6 [106,107]. Ferguson documented that N-nitrosopiperidines are carcinogenic in nature and blocking of one of the à ¯Ã‚ Ã‚ ¡ position by an alkyl group significantly reduces the carcinogenic activity [108]. Lijinsky and Taylo r have also supports that blocking of à ¯Ã‚ Ã‚ ¡ positions to the N-nitroso group by methyl groups reduces the carcinogenic activity [109]. 3t,5t-Dimethyl-2r,6c-diarylpiperidin-4-one hydrochlorides 59-61 have shown anti-histaminic activity [110]. Furthermore, 3t,5t-dimethyl-2r,6c-bis(4-hydroxyphenyl)piperidin-4-one 62 and 3t-methyl-5-substitutedphenyl-2r,6c-diarylpiperidin-4-ones 63 showed antimicrobial, insecticidal and antihistaminic activities [111]. 2,3,6-Triarylpiperidin-4-ones 64 and their oximes exhibits marked bactericidal, fungicidal and herbicidal activities [104]. N-Substituted piperidin-4-one 65 and its derivatives 66 and 67 exhibited potential Juvenile hormone activity on Bombyx mori [112]. N-methyl-3E,5E-bis(arylidine)piperidin- 4-ones 68, possessing a variety of aryl and heteroaryl groups, showed antiviral and antitumor activities [98]. 3E,5E-Bis(benzylidene)piperidin-4-one 69, 1-acryloyl derivatives of 69, and 70 the adduct of 2-mercaptoethanesulfonic acid 71 as well as 3E,5E-Bis(thienylidene)-piperidin-4-ones 72 have shown antitumor activity towards human carcinoma cell lines Caov3, Scov3 and A549 [113]. Furthermore, modification of position 3 of the piperidin-4-one nucleus as well as a substitution of certain functional groups in the para position of phenyl ring attached to C-2 and C-6 carbons of the piperidine moiety would result in compounds of potent biological activities. Hydrazones Hydrazones are a class of organic compounds with azomethine -NHN=CH- proton that constitutes an important class of compounds for new drug development [10,97,98]. Hydrazone are formed usually by the action of hydrazine on ketones or aldehydes. Hydrazide-hydrazone derivatives receive the attention of various medicinal chemists as a result of their effectual biological potencies viz., antimicrobial, anti-tubercular, and also anticonvulsant actions [10,114-116]. Some hydrazones is known to act as herbicides, insecticides, nematocides, rodenticides and plant growth regulators. Several studies have documented the spasmolytic activity, hypotensive action and activity against leukaemia, sarcomas and other malignant neoplasms [114-116]. Many of the physiologically active hydrazones have applications in diseases like tuberculosis, leprosy and mental disorder are characterized by the presence of the triatomic group (>C=N–N73 [117]. Hydrazones are also useful in detection, determination and isolation of compounds containing the carbonyl group and many other metals [10]. Syringaldehyde hydrazones 74 and 6-nitro-3,4-methylene-dioxophenyl-N-acylhydrazone 75 exhibits antioxidant properties [118,119]. Hydrazone and its substituted derivatives showed good antibacterial, antifungal, anticonvulsant, antitubercular, anticancer and antitumor activities. 1-[4=[(2-[(4-Substitutedphenyl)methylene]hydrazine] carbonyl)phenyl]-3-substituted thioureas 76 exhibited good clinically active tuberculostat [120]. Some coupling products from 4-aminobenzoic acid hydrazones 77 and (7-Hydroxy-2-oxo-2H-chromen-4-yl)acetic hydrazide 78 showed antimicrobial activity [121,122]. A series of 4-fluorobenzoic acid (substituted methylene/ ethylidine) hydrazide derivatives 79 showed the chemotherapeutic antituberculosis activities [123]. Hemalatha et al have documented the antibacterial and antifungal activities of N-nitroso-2,6-diarylpiperidin-4-one semicarbazones [124]. Some bicyclic semicarbazones and thiosemicarbazones 81 showed a wide variety of biological activities [124]. The significance of fusing heterocycles Heterocycles possess an enormously diverse group of compounds, are widely distributed in nature. Heterocycles can be easily manipulated and modified by organic synthetic methods to increase or decrease reactivity. They are used extensively as intermediates in various reactions as well as building blocks in organic synthesis. Novel libraries of biologically diverse heterocyclic compounds have been synthesized by incorporation and substitution of a wide range of functional groups (ring activators or deactivators) and their positions around the ring of heterocycles. Several studies provide evidence that combination of two bio-active heterocyclic moieties together leads to the production of novel and biologically important compounds with the anticipation of several promising pharmacological agents [4,125]. Based on the above features discussed under 3t-Alkyl-2r,6c-diarylpiperidin-4-ones, 2r,4c-Diaryl-3-azabicyclo[3.3.1]nonan-9-ones and hydrazones, we have developed the system that fuse 3 -azabicyclonones/piperidin-4-one pharmacophore and hydrazide moieties together to produce the corresponding hydrazones with the anticipation of several promising antioxidant, anticancer and antimicrobial agents arising. The relevant technique used to elucidate the structure of the newly synthesized compounds Specialized spectroscopic instruments can be used to generate information that enables the determination of the structure of an unknown organic compound. This includes Infrared spectrometry (IR), nuclear magnetic spectrometry (NMR) and elemental analysis. Among all available spectrometric methods, NMR is the only technique which offers a complete analysis and interpretation of the entire spectrum [126,127]. A few of the strategies of NMR experiments that are used in determination of different compounds are described as follows. NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY Nuclear magnetic resonance spectroscopy, one of the most versatile techniques for elucidation of structure of organic compounds, has shown a tremendous progress due to improved experimental technology and novel approaches. In NMR, the most useful information comes from the interactions between two nuclei, either through the bonds which connect them (J-coupling interaction) or directly through space (NOE interaction) [126-128]. Interpretation of NMR spectra is well understood from the following basic information gathered from NMR spectra. 1) Chemical shift, which identifies the type of proton based on their electronic environment, 2) Spin-Spin splitting patterns, which identifies neighbouring protons, 3) Peak Area, which is proportional to the number of protons giving a particular resonance line, 4) The observation of a triplet and a quartet spin state confirming usually the presence of an ethyl group (CH3CH2) and 5) The observation of ÃŽ ´ values between 7.2-8.0 indicates that the structure contains a benzene ring (benzyl proton) [126-130]. Generally, three approaches are used in NMR spectroscopy methods. These include one dimension (1D), two dimensions (2D) and three dimensions (3D). The first approach of 1D-NMR (1H DEPT, 13C, 15N, 19F, 31P, etc.) generates good information about the structure of simple organic compounds. However, it is overcrowded in case e of larger molecules. The second approach of 2D-NMR (COSY, DQFCOSY, MQFCOSY, HETCOR, HSQC, HMQC, HMBC, TOCSY, NOESY, EXSY, etc.) is used for the further larger molecules. A 2D-NMR spectrum also becomes complex and overlapping in case of further very large molecules like proteins. Therefore, multi-Dimensional-NMR (Homonuclear and Heteronuclear) are generally used to achieve high resolution and reduced overlapping in spectra of very large molecules [126,128,129]. This section further describes the general interpretation of structure of different organic compounds by different NMR techniques. 1D NMR SPECTROSCOPY 1H-NMR: Spin transitions of only hydrogen nuclei are observed in in 1H-NMR spectroscopy. Table 1 represents different ÃŽ ´ values, couplings, coupling constants and chemical shifts of 1H nuclei processing in different chemical environments. Commonly, ÃŽ ´ value scale of 1H-NMR ranges from 0-10 ppm with respect to Tetra methyl Silane (TMS) as internal standard. 1H-NMR spectral interpretation can be best understood from table 4 [126,131]. 1H Chemical shifts Because of variations in the electron distribution, the variation of nuclear magnetic resonance frequencies of the same kind of nucleus is referred to as chemical shift (symbolized by ÃŽ ´). Quantitative chemical shift are measured in frequency (Hertz) relative to a standard, Tetra methyl silane (TMS). Characterization of the structure of a molecule is depending upon the position and number of chemical shifts [111,112,115]. The chemical shift range of 1H nuclei can also be understood from a chart given in figure 1 [126].The chemical shift values for methyl protons attached to groups of varied electronegativity are given below [127]: CH3I-2.16 CH3Br-2.18 CH3Cl-3.05 and CH3F-4.26 ppm, The electron density around the proton affects its chemical shift. Because of the e- density around the H nuclei, the CH3 protons come to resonance at higher ÏÆ' values as the electronegativity of a functional group is increased. Electronic charge surrounded to H nuclei shields the nucleus to some extent from the influence of the applied field. The magnetic flux overcomes this shielding effect in order to bring a proton to resonance. Thus, the higher the electron density around the proton, the greater the induced diamagnetic effect and the greater the external field required to overcome the shielding effect. Electro-ve groups like fluorine in CH3F withdraws e- density from the CH3 group (-inductive effect). This leads to de-shielding by lower value of an applied magnetic field in order bring the methyl proton to resonance. Fluorine is more electro-ve than Cl, thus the proton in CH3F appears at a higher ÃŽ ´ values than those in CH3Cl. The chemical shift positions for protons attache d to C=C in alkenes is higher compared to that of accounted by electronegative effect alone. Alkene and aromatic protons appear at high ÏÆ' values while alkyne C≠¡C protons appear at a relatively low ÃŽ ´ value [126,127,132]. The magnetic field created by pi electrons or rings is referred to as Magnetic anisotropy, which describes an environment where different magnetic fields are found at different points in space. Since Pi electrons are held less strongly than sigma electrons, pi electrons are more able to move in response to the magnetic field. The anisotropic effects of the à ¯Ã‚ Ã‚ ³ electrons of C-C bond is low compared to those of the circulating à ¯Ã‚ Ã‚ °-electrons. The equatorial protons in cyclohexane resonate at 0.5 ppm higher than the axial protons. This is due to the anisotropic effect of the à ¯Ã‚ Ã‚ ³-electron in the CÃŽ ²-Cà ¯Ã‚ Ã‚ § bonds [127,133] (Figure. 2). [R1]Specify which biological activity

Changes In The NHL :: essays research papers

Changes In The NHL   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚     Ã‚  Ã‚  Ã‚  Ã‚  In the past there were more goals, less penalties, and never any talk about an Olympic size rink, all that has changed in the last few years. The NHL has changed since the introduction of, the new crease rule, the enforcement of obstruction, and the request for an Olympic size rink.   Ã‚  Ã‚  Ã‚  Ã‚  The new crease rule is the most controversial rule change that the NHL has ever introduced. There has been less goals since the players have not been allowed to have even a toe in the goal crease when a player scores a goal. The old rule was that players were allowed to be in the crease as long as they don’t interfere with the goalie. The NHL has since made the crease smaller so that there is less chance of a player being in the crease, but that hasn’t changed the fact that players are still in the crease when a player scores a goal. On average there has been at least two goals a night called back since the new crease rule.   Ã‚  Ã‚  Ã‚  Ã‚  The obstruction rule has been one of the best rule changes ever in the NHL. Players are not allowed to interfere with other players if they are going into the play were the puck is. This new rule has cleaned up the game of hockey tremendously. Some of the obstruction calls are, obstruction hooking, obstruction holding, obstruction tripping, so on, and so forth. When the obstruction rule first came into effect there was way more penalties, now the penalties are becoming less.   Ã‚  Ã‚  Ã‚  Ã‚  The request for an Olympic size rink still has not been approved by the NHL. The NHL has talked about upgrading their regular size rink to an Olympic size one. If the NHL comes to an agreement to go to the Olympic size rink, the game would be a lot faster, a lot more open, and there would be many more great set up plays.

Heart Of Darkness :: essays research papers fc

The Horror Heart of Darkness by Joseph Conrad is a novel where the main character Marlow is telling a story of a trip to the Congo. This novel is said to possibly be an autobiography of Conrad’s life at sea. This is said because Conrad was a seaman for a many years and went into Africa many times. The story is so powerful that even after 100 years, we still struggle with its meaning. This story has been retold by Francis Ford Coppola in the film Apocalypse Now. Chinua Achebe has recently explored Conrad’s ideas on imperialism. Achebe believed Conrad’s book presented a racist view of the people of Africa and Achebe in his own book, Things Fall Apart, presented imperialism through the eyes of the Africans. The story of Heart of Darkness is being told to four men on the deck of the Nellie. The story being told is about one of Marlow’s expeditions to the Congo in search of an Ivory hunter named Kurtz. When Marlow found Kurtz in the Congo, Kurtz had "gone native" Marlow found, "a head that seemed to sleep at the top of that pole," outside of Kurtz’s house and Kurtz had been hunting with tribes in the area (Conrad, 73). When Marlow arrived Kurtz, was ill and dying. Kurtz cried out the words "The horror! The horror!" right before he died (Conrad, 85). These words cried out by Kurtz as he died created the most important passages in Heart of Darkness. The way this one passage is interpreted determines how the book is interpreted. One interpretation is that the "horror" is death and Kurtz is realizing he is dying. Kurtz is horrified at the thought of dying and is crying out in pain of the realization. Kurtz may be afraid to die in the heart of darkness. Kurtz may be afraid to die knowing that he will never see his intended again and he may feel guilty for leaving his intended for his savage life. This interpretation shows a book about lost love and guilt for finding a new life. This interpretation is one of the less complex and uninteresting interpretations. Now here is a more interesting and complex interpretation. Some view Heart of Darkness as a racist book. This interpretation comes from the view that the "horror" Kurtz is identifying is his being brought "down" to the African ways. This interpretation sees the African ways as uncivilized and horrid to Kurtz when he realizes he was at their level.

The Unique Corporate Culture in Google

The Unique Corporate Culture in Google Executive Summary The internet giant of search engine â€Å"Google†, always rated for the â€Å"Best Workplace†, â€Å"Best Employer† in the recent ten years. Why? Except the professional technology, Google’s great and unique corporate culture made so. The feature of Google’s corporate culture is equality, free and human oriented.The company provide the most luxury and comfortable work environment to its employee, encourage them relax more, play hard and work hard. From Google’s case, more and more companies realized the perks and benefits for the employee are no longer only medical, insurance, overtime pay, free coffee and two weeks holidays. In Google, nobody need to punch the clock, you can work in your own â€Å"time zone†.If you don’t want to leave your pet in the working time, bring it in your office, you can stay with it in every minute. You don’t need bring the lunch box to t he company, because it has free breakfast, lunch and dinner every day. Vast kinds of facilities are well-established. Like the professional massagist, the gym, the massage chair, the bicycle, the dry clean laundry, the slides, the electronic scooter, the oil change, and so on.Everything seems great, but if the employee has other demand, they can speak to the founder or CEO directly, maybe the request would be excessive or crazy, but if it is feasible, Google will satisfy employee in every possible way. The open policy reflects the equality in Google. Every employee can see the boss and co-workers work plan and schedule. Google think this way can let all employees get the information about company’s program progress and developing direction, make them feel they are trusted and will be one of the groups always.

Determine Disinfectant and Antiseptic Effectiveness Using Zone Inhibition Method

Lab Report Title Page: Determine Disinfectant and Antiseptic Effectiveness Using Zone Inhibition Method Prepared for: By: Date: Introduction Page: Abstract This study is to examine the effects of different types of disinfectants by disk diffusion method using common agents such as Betadine, Clorox, Crest, Kiss My Face, Listerine, and Lysol. Wound care and general cleaning of home surfaces is a part of daily activity for many of the general population. Knowing which agents are effective against the bacteria that most commonly cause infection, disease, and illness allows educated decisions on which agents to use. We compared the bactericidal effectiveness of 6 common agents widely used by the general public against 3 common bacterial organisms. Introduction Sterilization kills all organisms in or on an object or substance. Disinfectants and antiseptics do not sterilize since many types of organisms and spores are not killed. Disinfectants are described as antimicrobial agents that are used on inanimate objects such as an instrument or structural surfaces. The term antiseptic is usually applied to antimicrobial agents that are used on living tissue such as skin and throat mucosa. A disinfectant must be capable of killing pathogens while it is in contact with them, so that they cannot grow again when it is removed. This action is said to be cidal (lethal), and it is described according to the type of organisms it kills as bactericidal, sporicidal, fungicidal, virucidal, etc†¦ If the antimicrobial substance merely inhibits the organisms while it is in contact with them, they may be able to multiply again when it is removed. In this case, the agent is said to have static activity and may be described as bacteriostatic, fungistatic, etc†¦ Microorganisms of different groups are not uniformly susceptible to chemical disinfection due to the structures of their cell walls. As an example, Mycobacterium are more resistant than most other bacteria because of their waxy cell walls. Of all microbial forms, bacterial endospores display the greatest resistance to both chemical and physical agents of disinfection. The efficacy claimed for a given disinfectant in killing vegetative bacterial species may have no bearing on its ability to destroy bacterial or fungal spores, mycobacteria, some viruses or prions. A number of factors must be considered when choosing a disinfectant besides type of organism. These include exposure time, concentration of the antimicrobial agent, temperature, optimal pH activity of the antimicrobial agents, the concentration of the microorganisms present, and the toxicity of the agent for skin or its effect on materials to be disinfected. Here we will test the effectiveness of various antimicrobial substances by inoculating culture plates with the test organisms and then applying the disinfectant/antiseptic to the inoculated plate by a filter paper disk that has been dipped into the disinfectant/antiseptic. This is a disk diffusion method that is similar to the method used to test the effectiveness of various chemotherapeutic agents. We will then measure the zone-of-inhibition. With this method, the presence of such a clear zone (lack of growth) surrounding the chemical shows either the cells have been killed or that their growth has been inhibited. A zone of inhibition does not discriminate between bacterio-static and bactericidal chemicals. The 6 agents we will be testing are: Betadine (B) – A povidone-iodine preparation used mainly for skin disinfection and wound treatment. Kills a wide range of disease-causing organisms including bacteria, fungi, many viruses, and most micro-organisms. Does not affect hydrophilic viruses such as polyomavirus and PBFD. Clorox (C) – A biguanide preparation of Sodium Hypochlorite used mainly for surface cleaning in various environments such as homes and hospitals to kill microorganisms. Bleach is effective as a disinfectant and kills many micro-organisms, but is not a viable solution to the spread of tuberculosis, bacterial spores and Chlamydia. Crest (Cr) – A widely used antimicrobial for oral bacteria and biofilms. Especially useful on Gram-negative micro-organisms such as Aggregatibacter actinomycetemcomitans, Campylobacter rectus, Eikenella corrodens, and Fusobacterium nucleatum. Kiss My Face (Kf) – An organic alternative to typical alcohol based mouthwashes using aloe vera as antimicrobial agent and grapefruit extract as a polyphenol. Proven useful with Trichophyton mentagrophytes and Staphylococcus aureus. _ _. Listerine (Li) – An alcohol based antiseptic mouth rinse containing the active ingredient ethanol which is toxic to bacteria at concentrations of only 7%. Reduces dental carries, plaque and gingivitis. Lysol (Ly) – A O-phenylphenol preparation of cresols used for surface cleaning in various environments such as homes and hospitals to kill microorganisms such as fungi, Tuberculosis, certain viruses,_ staphylococcus_ and Pseudomonas bacteria. Does not kill nonenveloped viruses, such as _parvovirus, polyomavirus, papillomavirus, adenovirus and reovirus_, nor will they kill all bacteria types. The three common bacteria we will be testing against are: Pseudomonas aeruginosa – An ubiquitous environmental organism associated with whirlpools whereby infection is caused by immersion in contaminated water. Staphylococcus aureus – A normal flora organism on the skin surfaces of most healthy humans. Escherichia coli – A large and diverse group of organisms associated with fecal remnants that have been ingested causing infection. Materials and Methods Page: Materials and Methods T-Soy plates (TSA) – Lawn spreading method Sterile swabs Forceps Sterile filter paper disks Disinfectants/Antiseptics We will follow the specific instructions to carry out this experiment as noted in Lab 16 p90 of Symbiosis by Pearson. Results Page: Results and Discussion This experiment was conducted to show how different disinfectants and antiseptics kill bacteria. The results of our experiment under normal room conditions on the TSA agar were as follows: Conclusion Page: Conclusion Previous research has shown that if an antiseptic disinfectant agent does not kill bacteria, the risk of infection is significantly higher. We used a Gram-negative (P aeruginosa), a Gram-positive (S aureus), and a Gram-negative (_E. coli_) bacterium for bactericidal testing procedures. We allowed the TSA agar to mature over a 7 day period and then noted our results by viewing and measuring the zone inhibition (mm). Findings were that while all had an effect, there were differences among how effective each agent was against each strain of bacterium used. Surface cleaning agents – Lysol was most effective against S. aureus and E. Coli, while Clorox did significantly well with all three bacterium. It appears from our findings that Clorox is the most effective disinfectant and antimicrobial of the six agents tested. Oral care agents – The effects of Listerine were less than stealer, while the organic product Kiss My Face was more effective with all three types of bacteria. Crest rated low as an effective agent for all three types of bacteria. It is important to note that the standard deviation rose as high as 7. 8, which is a significant difference in the resulting data accuracy. Literature Cited Pearson, 2010. Symbiosis Lab 16 Disk Diffusion Assay to Determine Disinfectant and Antiseptic Effectiveness, pp. 89-91. Pearson Custom Publishing Vicki S. Rabenberg, Christopher D. Ingersoll, Michelle A. Sandrey, and Mary T. Johnson. The Bactericidal And Cytotoxic Effects Of Antimicrobial Wound Cleansers. 2002. Centers for Disease Control and Prevention http://www. cdc. gov/nczved/divisions/dfbmd/diseases/ecoli_o157h7/index. html#spread Violet I. Haraszthy, DDS, MS, PhD; Joseph J. Zambon, DDS, PhD;Prem K. Sreenivasan, PhD. The Antimicrobial Efficacy of Commercial Dentifrices Featured in General Dentistry. 2010 Agarry O. , Olaleye M. T, and Bello-Michael, C. O. Comparative antimicrobial activities of aloe vera gel and leaf. African Journal of Biotechnology Vol. 4 (12), pp. 1413-1414, 2005. ZDENKA CVETNI, ANDA VLADIMIR-KNE. Antimicrobial activity of grapefruit seed and pulp ethanolic extract. Department of Microbiology Faculty of Pharmacy and BiochemistryUniversity of Zagreb in conjunction with the Croatia and Department of Pharmacognosy Faculty of Pharmacy and Biochemistry University of Zagreb, Croatia. 2004.

The Study of Simon’s Character in Lord of the Flies

From a Freudian perspective, the tripartite components of the human psyche—id, ego, and superego —are enacted symbolically by Jack, Ralph and Piggy, in the respective order. Simon’s existence in the story serves no purpose to portray this psychic mechanism whereas the other three main characters wrestle with each other and attempt at role balancing in response to survival need. Jack is the id-ridden one, who follows the primitive instinct of the body, and hunting and killing to his satisfaction at any cost.Obviously, even as one of the Hunters, Simon’s apathy about hunting and his abstinence from eating meat evince the dominion of his mind over his body. Considering the superego, readers might confuse Simon with Piggy and equate their roles as both of them stand for the ethical voice on the island, trying to maintain moral standards by which the ego, Ralph, operates. In fact, the characteristics possessed by Piggy are more consistent with the core of super ego.Intending to be socially conventional, Piggy constructs an ethical frame according to the rules imposed by adults, by which he emphasizes their importance whenever in the face of injustice. In contrast, Simon knows man’s essential illness as a result of long time introspection, in a natural shelter concealed in undergrowth from humanity. On the other hand, Simon’s altruistic tendency, shown by his feeding of the hungry horde of neglected littluns, intensifies his saintliness, as the divisions of the psyche essentially embody three levels of desires.Recalling the scene when Simon, Ralph and Jack find the candle-like plant, the difference in their interactions with the outside world is clearly demonstrated. Ralph denies their illuminating functions and Jack shows contempt for their inedible quality. They associate an external object with its possible practical use in reality. Simon differs in â€Å"seeing† the candle buds, treating an experience as a pure comm union, through which insights would have developed according to his sense of impression. Such internal individual perception is limited to affect his inner world of beliefs, but never the others’.This account for the great difficulty Simon encounters when he tries to explain the beast that he â€Å"sees†, actually a concept, is true when those utilitarians cannot even understand Piggy’s practical and logical consequence. Another item worth mentioning is Simon’s inclination to be internally or spiritually satisfied—he detects the candle buds after telling his companions that he is hungry. Candles are a commonly used decoration in religious venues, generally meaning a connection to spirit. Similar instance occurs when the others think that he would be bathing in the lagoon, he seeks solitude— a cleansing of his mind.Although realizing that the beast-innate evil nature of mankind does exist, Simon is steadfast in his faith in original virtue of humanity, which was once heroic and sick. If the island is personified as a female, Simon is prone to embrace its beauty and tranquility, meditates alone in a glade surrounded by white glimmering flowers of the candle buds, which symbolize mankind’s spiritual purity. He is not ever disturbed by the affirmed discovery of the beast, and feels completely at ease with going by himself across the forest to rejoin Piggy’s group.The other boys interpret the island in an opposite manner, and become more aware of her danger and hostility as time passes by, giving vent to this restlessness by claiming the existence of the beast. During an assembly, Simon makes a valiant and unsuccessful effort to indicate the essence of the beast- â€Å"maybe it is only us†, implying that he expects the beast is one of the two dimensions of our nature . Then he questions the crowd, asking â€Å"what is the dirtiest thing there is? †, assuming mankind’s natural tendency to h ave an affinity with the clean- the virtuous side of himself.This belief is radically undermined when he witnesses the brutal killing of a sow with a sense of violent sexual imagery comparing it to a rape, rendering the glade a filthy and bloody place. The concrete ugliness of the body—the spilled guts and the pungent smell, juxtaposes with the abstract one—the hunters’ indulgences to bestial impulse . Nature, which he used to hold in regard for her sacred beauty, is tainted with the sin of flesh, where its root is man’s body, an indispensable part since birth.The pig’s head on a stake, foul but magnetizing a flock of flies, changes into the Lord of the Flies in Simon’s hallucination, in which he remains conscious, suggested by his comment on the self-proclaimed beast- merely â€Å"a Pig's head on a stick†. The Lord of the Flies is an externalization of human sin envisaged by Simon, acting as a medium for presenting his inner conflict with choosing between compliance and self-preservation, the ignorant lie and the despairing truth, at last the abusiveness of evil and the fragility of virtue.Through the monologue in a form of phantasm, Simon refutes his previous notion of human nature and brings a new definition to it—the beast is part of us instead of being in dichotomy; â€Å"Fancy thinking the Beast was something you could hunt and kill! † he said to himself. He comes to recognize his own plight and that of the island, having a premonition of death as the Lord of the Flies promises to have â€Å"fun† on the island. Awake, Simon defies the threat and accepts his fate, as â€Å"What else is there to do? †.He undergoes a physical and spiritual transformation-â€Å"The usual brightness was gone from his eyes and he walked with a sort of glum determination like an old man†. The unmasking of the supposed beast on the top of the mountain which he finds to be a dead parachutist, conf irms his belief- the beast is within us. Before climbing down the mountain to make public the truth, he frees the corpse of the fallen man from the bondage in compassion, with a significance of â€Å"dust thou art, to dust returnest†, enabling nature to purge the sin from the body.In his last and desperate attempt in liberating mankind from sin, Simon fails, albeit his love and unwavering faith in mankind, believing that confronting the truth would achieve them a conversion into goodness. His death is inevitable, as a testament to his hypothesis—he stumbles into a circle of insanity before he can explain the nonexistence of the beast, then being torn apart by a group of dancing and chanting â€Å"beasts† that have their predatory instinct unleashed and their identities lost. In the arms of the sea, a sign of life’s eternality, Simon finds the homeland of his soul.The ‘strange, moonbeam-bodied creatures with fiery eyes’ that forms a halo aroun d his head give a little consolation to his death, but they are actually low form of life similar to flies, which are aesthetically accepted by nobody. It is Simon’s noble spirit, under that decaying body, makes them glow. Simon’s death produces no corrective effect on the boys’ ignorance of their inner beast, as ironical as his death, most of the boys give in to such bestiality afterwards so as to gain a psychologically completeness of the brutalities that they have committed, and the island soon ends up being an earthly hell in blaze.The participation of Ralph and Piggy in Simon’s murder, driven by the need to join the â€Å"demented but partly secure society†, indicates the irreversible loss of the boys’ innocence to animality, as the two are the only left on behalf of rationality, yet being insensible to the internal beast, believing that ‘evil is somewhere else’. Even for Piggy, who reasons scientifically, has his own limit ation to reach the understanding of their defects by nature, and simply concludes Simon’s death as an accident when he ants to exculpate himself. This explains the futility of Science when tackling with the dark side of humanity. The story itself is a miniature of mankind history, and the reason for the collapse of a society can be inferred- neither determined by the fire nor the conch. The former represents technology—can be the first spark ever ignited but also a destructive atomic bomb, helps, at the same time, totally destroys civilization.And the latter refers to a democratic parliamentary system which Golding had elaborated on in his speech-â€Å"The moral is that the shape of a society must depend on the ethical nature of the individual and not on any political system however apparently logical or respectable. † Therefore, Simon is the final resolution for all chaos, who exemplifies the ideal moral that individual should have- he is temperate in sensual d esire, sacrifices for mankind’s welfare expecting nothing in return, sees through man’s latent ill nature but martyr for a faint possibility of healing it.Nonetheless, here comes the paradox- Simon is not a convincing character that can come to life. The author had him idealistically created and endowed him a propensity to put overly the spiritual above the material: basically, he does not express the normal desire to survive, neither in a primitive society nor a civilized one, for the structural model of psyche is inapplicable to him. Again, he spontaneously has an insight into human nature with a covert thinking process, likely to produce an ill-founded outcome for his reliance on idealism (of philosophy) if being in reality.Rather than calling him an idealistic thinker, he suits better to the role of a visionary, having a supernatural intuition that Ralph could go home eventually. Thus the only way to justify for his motivations is that he is deliberately intended t o be a Christ figure, admitted by Golding in an interview, in which he also said, â€Å"What so many intelligent people†¦find, is that Simon is incomprehensible. †¦a person (Simon) like this cannot exist without a good God.Therefore the illiterate person finds Simon extremely easy to understand†¦Ã¢â‚¬  In â€Å"Lord of the Flies†, Simon is designed to be a symbol of religion, because of the parallelism between his fate and Jesus’s which is found by many critics. Unlike Jesus, Simon’s death is not redemption of the world from sin. It indeed coincides with an assertion made before the outbreak of World War II, by a German philosopher, Friedrich Nietzsche—†God is dead†, literally meaning that the conventional Christian God is no longer a feasible source of any absolute moral principles.

Howard Gardner And His Theory Of Multiple Intelligences Education Essay

Howard Gardner, born on July 11th, 1943, is one of modern twenty-four hours ‘s greatest psychologists. ( Smith ) He was born in Scranton, Pennsylvania to parents who escaped from Germany because they were Jewish. ( Winner ) The holocaust was an influential factor in his life. ( Gardner ) Another great influence in his life is the decease of his brother Eric, although his parents seldom talked about the affair, it significantly impacted his thought and development. ( Smith ) In other words, his household and equal greatly shaped who he became today. ( Myers 118 ) He was a superb immature kid, who ended up traveling to Harvard University with a grade in Law but his involvement in psychological science and the societal scientific disciplines grew. ( Gardner ) Finally he developed his theory of Multiple Intelligence in 1983 in his book Frames of Mind: theory of multiple intelligences. ( Gardner ) During that clip period psychological science was progressively popular. For illustrat ion, a outstanding field during the 80 ‘s and 90 ‘s is cultural psychological science which assumes the thought that civilization and head are inseparable. ( â€Å" Cultural Psychology † ) Besides that clip period contained a batch of economic, societal and general alteration which makes his new thought more acceptable. More significantly the fact that he is American agencies that he grew up in a free thought society so he can take from what he learned and transforms it into what he believes is true so base on balls on his sentiments. Three other psychologists who influenced him greatly are Jean Piaget, Jerome Bruner and Nelson Goodman. ( Gardner 3 of 7 ) Jean Piaget who deals with the nature of cognition and how worlds can bit by bit to obtain it, make it, and utilize it. Besides, Jerome Bruner contributed to cognitive psychological science and cognitive acquisition theory in educational psychological science. Goodman dealt with inductive concluding based on human wont. ( Gardner 3 of 7 ) The three of them goes along with Gardner ‘s statement of how kids learn cognition. Besides their plants caused Gardner to go more interested in societal scientific discipline. Waldorf instruction developed in the early 1900s by Rudolf Steiner was similar to Gardner ‘s thoughts. ( Why Waldorf Works ) It was about incorporating practical, artistic and conceptual elements into larning. This instruction emphasizes imaginativeness and creativeness so that pupils can develop into free, morally responsible and incorporate persons. The first Waldorf School was opened in Germany in 1919 and now there are many schools get downing to utilize methods of Waldorf instruction. ( Why Waldorf Works ) Last an thought credited to be developed by Jerome Bruner in the 1960 ‘s is find larning which promoted custodies on tilting where scholars draw from his or her ain experience and anterior cognition. ( â€Å" Discovery Learning ( Bruner ) † ) So there were many factors that influenced his thought and that pushed him to develop his theory. His theory trades with how worlds have many different ways to larn and treat information. ( â€Å" Howard Gardner ‘s Multiple Intelligences theory † ) He believes that everyone has different degrees of intelligence in each class which is why some kids learn some things faster than others. Gardner believes that intelligence is normally defined by psychometries but it does non adequately describe people ‘s broad mixture of cognitive abilities. IQ trials can sometimes be taken excessively earnestly but it can non find future success ( Gardner 3 ) . Even college aptitude trials are â€Å" thinly cloaked intelligence trials. † ( Myer 432 ) For illustration a kid that takes longer to larn generation does non intend the kid is dense but that the kid is more intelligent in other countries. In the facet of instruction, Gardner wants to prioritise because he believes the cognition we learn is superficial, â€Å" a stat mi broad an inch deep † . ( Guignon ) He r ecognizes that â€Å" Students learn in ways that are identifiably typical † so he promotes more pupil centered as opposed to teacher centered larning which is a really practical thought. Harmonizing to Garner, there are 8 perchance 10 intelligences ; spacial, lingual, logical, bodily, musical, interpersonal, intrapersonal, and realistic. Spatial is the ability to visualise with the head ‘s oculus. ( Chapman ) Linguistic intelligence trades with words, spoken or written. These people learn best by reading, taking notes, listening to talks, and treatment. ( Chapman ) Logical-mathematical is about logic, abstractions, concluding, and Numberss, concluding capablenesss scientific thought and probe traditional constructs of â€Å" intelligence † or IQ. ( Chapman ) Bodily-kinesthetic is the control of one ‘s bodily gestures and the capacity to manage objects skilfully. Musical intelligence trades with sounds, beat, tones, and music sing, play musical instruments. ( Lane ) Interpersonal intelligence is about interaction with others. They are largely extraverts, characterized by their sensitiveness to others ‘ tempers, feelings, dispositions and motiv es and collaborate good with others. ( Lane ) Intrapersonal is the introverted and self-reflective capacities. Those people are introverted but good at decoding their ain feelings and motives. ( Lane ) Lastly is realistic who deals a batch with nature associating information to one ‘s natural milieus. The 9th intelligence is non to the full confirmed yet but it is experiential which is about contemplating phenomena or inquiries beyond centripetal informations. And eventually, the ten percent is moral intelligences covering with moralss and the value of life. ( Chapman ) His theory greatly changed the heads of many and started the development of more across-the-board schools. Traditionally, schools have highlighted the development of logical and lingual intelligence but many pupils do non larn good in that environment. ( Lane ) Gardner ‘s theory argues that pupils will be better served by a wider vision of instruction, wherein instructors use different methods to learn all pupils non merely the few that are intelligent logically or linguistically. ( Guignon ) Although, many instructors see the theory as simple common sense and some even say they already know that pupil learn in different ways, Gardner ‘s system has non been accepted by most faculty members instructions. ( Guignon ) Some schools nevertheless, have developed to better fit Gardner ‘s thoughts. For illustration, one of the most celebrated schools that implement Gardner ‘s theory is the New City School in St. Louis, Missouri. This school has been utilizing the theo ry since 1988 ( â€Å" Why New City School † ) There has been much unfavorable judgment for his theory though. Some say he uses the word intelligence in topographic point of ability. ( Gilman ) Others say that he has non settled on a individual definition of intelligence though he admits himself that he has no fixed definition. ( Gilman ) Last and most significantly, he has no empirical grounds for this theory. ( Smith ) In fact, some neurological research disproves his theory and his old plants has major defects. ( Smith ) Recently, the current No Child Left Behind act passed by the Bush disposal does non embrace his theory at all because the Act is about holding pupils all pass standardized trials while he wants to acquire rid of those trials in order to make out to every kid ‘s demands. ( â€Å" No Child Left Behind Act ( NCLB ) | ESEA † ) His theory affects us so much today because it relates to instruction ; Gardner goes into how schools merely teach superficial cognition significance schools teach a batch of everything but non in deepness into anything so some childs may stand out in one country but non the other. ( Gardner ) There is excessively much shoal cognition so he suggests that kids should larn and really understand constructs non merely larn for taking a trial. ( Smith ) If he obtains more support for his theory, the whole instruction system will hold to be changed. But his thought of an instruction system should work good because this will assist do the instruction system m ore just and embracing for all childs. Right now, some kids that may look like they are neglecting school but their failure is non because they are dense but because the manner topics are taught in school is non how he or she can grok and use. ( Gardner ) Even though Gardner ‘s theory is appealing, it will likely non work because there is no widespread support particularly from authorities. ( No Child Left Behind Act ( NCLB ) | ESEA ) Besides, single instructors particularly in lower classs have unconsciously adapted parts of his theories but because in higher classs there is more lecture manner instruction, his theory seldom applied to higher instruction. ( Guignon ) Furthermore there is so much contention over this theory because it keeps on altering and there is no cogent evidence which makes it difficult to wholly believe this theory. ( Smith ) Additionally, since Gardner is still alive, he can maintain on altering his theory and acquiring more grounds and support. ( Gardner ) Lastly, some schools have already adapted his theory such as the New metropolis school. This school published many books about implementing this theory in more schoolrooms such as the school ‘s instructors have produced two books for instructors, Observing Multiple Intelligences and Succeeding With Multiple Intelligences and the principal, Thomas Hoerr, has written Becoming a Multiple Intelligences School in add-on to many articles on the practical applications of the theory. ( â€Å" Multiple Intelligences Resources ) The school has besides hosted four conferences, each pulling over pedagogues from around the universe. ( â€Å" Why New City School † ) The school remains a valuable resource for instructors interested in put to deathing the theory in their ain schoolrooms. It is clear that Howard Gardner has had an of import impact on today ‘s psychological science universe and instruction. His continuity to â€Å" dispute an educational system that assumes that everyone can larn the same stuffs in the same manner † has decidedly made an impact in the universe as many schools have recognized the different ways kids learn. ( Lane ) Should his theory go more prevailing, who knows what out instruction system will be like in the hereafter.